Soy and cancer PART 2
Most cancers are sporadic, with mutations that occur at tumor headquarters without being inherited. Then what is the role of diet? How can the diet produce or to prevent these mutations and their consequences? Existing data shows, for example, that heterocyclic amines from roasted meat are carcinogenic, favoring colon and breast neoplasm; increased fat consumption, not only of animal origin, but also of sunflower oil, corn germ or soy, favors the emergence of breast cancer.
But various components of the diet have a protective action, inducing apoptosis, ie cell death, suppressing the spontaneous mutations by antioxidant action or influencing the cell proliferation and DNA methylation.
And what is the role of soy in preventing cancerous diseases?
In a symposium organized by the National Institute of Cancer in the US, held in 1990, was recognized that soy contains a series of anti-cancer substances.
Women who consume large amounts of soy products rich in isoflavones, and having higher concentrations of isoflavones in urine presents less risk and a lower rate of breast cancer.
Previous studies have shown that proteases inhibitors and phytic acid, some, in lack of information, have only bad words, and beta-sitosterol components constitute anticarcinogen action.
Isoflavones, especially genistein and daizdeina have the following useful actions against tumor development:
- removes free radicals, which causes mutations;
- are antioxidants, thus preserving the deoxyribonucleic acid oxidation;
- have antiestrogen effect, so useful in the prevention of breast and ovary cancer;
- combat or prevent mutations that can be the starting point of a tumor;
- prevents the cell proliferation when appropriate;
- inhibits the blood vessel formation necessary for tumors, which The Folkman endostatin expected fails.
The frequency of breast cancer and the number of tumors decreased in newborn mice, who were applied only three genistein doses. This suggests a potent anticancer activity, in a very critical initial phase of life through the direct effects of isoflavones on tissue that can subsequently cause cell cancer.
In the study published in the journal Clinical Chemistry (vol. 42, p. 955-964, 1996), by the Study Cancer Center in Hawaii, is shown that genistein and daidzein plays a major role in reducing the risk of developing malignancies, because populations exposed mainly to isoflavones through regular intake of soy have an less cancer incidence.
1 kg of soybeans contains 2g genistein and daidzein. The Hawaii authors studied the effect of soy products administered to the mothers that breastfed. It is known that breastfeeding is helpful not only for the mother, limiting fertility and protecting against ovarian and breast cancer, but especially for the child. Through breast milk, newborns are protected of a number of diseases such as mellitus diabetes, multiple sclerosis and various infections. In addition, the breast feeding is assigned a lower incidence of sudden death in children and a better intellectual development.
The authors study we refer to adds another breastfeeding advantage, namely a lower cancer frequency and its severity, both reduced significantly when newborn animals are treated with three doses of isolated genistein.
The authors believe that the reduced rate of cancer among asia populations is due to the increased consumption of soy, but not necessarily by the soy used in adult life, but due to after birth immediately exposure to isoflavones, in a critical period of life, through the breast milk that these substances contain. Isoflavones from breast milk are more easily usable for newborns than in foods that contain soy. Numerous other researches confirms that in prophylaxis of cancer diseases, soy plays an important role.